Bone Marrow Failure Diseases
Bone marrow failure diseases including aplastic anemia (AA), myelodysplastic syndrome (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) occur when the stem cells inside the bone marrow stop making enough healthy cells. These life threatening diseases can strike any person, of any age, gender or race, anywhere in the world. Each day 50 plus people are diagnosed with bone marrow disease in the United States alone. Most have never heard of their disease. All are searching for answers, support and hope.
The following information has been obtained from NIH. “In the past few decades, bone marrow transplantation (BMT) has become an integral part of the therapy of several hematologic and nonhematologic disorders. Despite the increasing clinical success rate of BMT, lung disease has remained a significant cause of morbidity and mortality among patients. Pulmonary disease is also a major cause of death after BMT. Clinically, the development of pulmonary inflammation and fibrosis after bone marrow transplantation in the absence of identifiable infectious agents has been termed idiopathic pneumonia syndrome (IPS). This syndrome accounts for as many as 50% of the total cases of pneumonia after BMT. Once established, the mortality rate of IPS can be as high as 70% and there are currently no promising therapeutic options available for treatment. The cellular and molecular mechanisms that give rise to IPS remain an enigma.” Julia passed away from IPS. Our hope is with continued research and funding, one child’s life may be saved and one Mom, Dad, Sister and family won’t have to endure the pain and suffering that Aplastic Anemia brought into our lives.
The following information has been obtained from NIH. “In the past few decades, bone marrow transplantation (BMT) has become an integral part of the therapy of several hematologic and nonhematologic disorders. Despite the increasing clinical success rate of BMT, lung disease has remained a significant cause of morbidity and mortality among patients. Pulmonary disease is also a major cause of death after BMT. Clinically, the development of pulmonary inflammation and fibrosis after bone marrow transplantation in the absence of identifiable infectious agents has been termed idiopathic pneumonia syndrome (IPS). This syndrome accounts for as many as 50% of the total cases of pneumonia after BMT. Once established, the mortality rate of IPS can be as high as 70% and there are currently no promising therapeutic options available for treatment. The cellular and molecular mechanisms that give rise to IPS remain an enigma.” Julia passed away from IPS. Our hope is with continued research and funding, one child’s life may be saved and one Mom, Dad, Sister and family won’t have to endure the pain and suffering that Aplastic Anemia brought into our lives.